Switching decks
This pales in comparison to the granddaddy of all cheating - the "cold deck". After all the shuffling and cutting has been done (everyone nicely pacified) the cheat can switch the deck for one he has stacked beforehand so that everyone has a real betting hand, but, of course, the cheat has the best one. Such a move is difficult, and may require distraction, but once done, no other sleights are necessary to win. The only defense is to simply always watch the deck. Many players believe that it is bad luck to look at your cards before the dealer is finished as you might miss your opponents' reactions to their cards, and might miss burning the dealer.
Collusion
One of the easiest ways to cheat at poker is with a partner or many partners, called collusion. This is basically playing differently against one or more players than you do against others at the table (in contrast to mechanics, which is directly manipulating cards or chips in violation of the rules). The gravity of such cheating ranges from the subconscious to the conspiratorial. Some common forms of collusion are soft play, that is, failing to bet or raise in a situation that would normally merit it because of your opponent; whipsawing, where partners at opposite ends of the table raise and reraise each other to trap players in between; and dumping, or deliberately losing to a partner (perhaps someone you are backing financially or with whom you have traded a percentage stake). Signaling (that is, trading information between partners) is probably the most egregious example of such cheating, but all of these are considered bad play and should not be tolerated at any poker game.
Especially in tournament poker, soft-playing a friend is cheating all of the other players out of their chance to see you bust your friend, getting them closer to the prize money.
For this reason, there are laws in some U.S. states saying that a husband and wife cannot play poker at the same table. Perhaps the easiest way to exploit such a situation is to agree to split the profits (after all, couples often have shared bank accounts). Even without any explicit collusion during the game, this reduces the variance of the team as a whole.
It should come as no surprise that two people sharing information about their hands enjoy a great advantage over the other players. Signals can take many forms, from the placement of the chips on the cards to Morse code tapings on the table. The key ingredient in all signaling systems is the ability to be repeated unobtrusively. In order for this advantage to make money it has to be done many times without someone realizing it. In a game where people (hopefully) are always watching each other, this can prove problematic. When a cheat is signaling the value of his hand to his partner, he is also signaling the value of his hand to everyone at the table. The result of a system of signals being figured out is nothing short of financial disaster. Some games are more susceptible to this kind of cheating than others: in Five-card stud and Lowball, for example, signaling the rank of just one card can give another player sufficient information to make many otherwise difficult decisions.
Should two people wanting to cheat be in close proximity, they might decide to hand-muck. That is, to switch hands or alter them in some way (though this particular form of cheating might be considered mechanics rather than collusion). A simple idea of this is to have two people sitting next to each other in a game of draw poker. While they receive two mediocre hands, they could switch certain cards between themselves in order to form a worthless hand and a winner. There are many sleight of hand methods to this. Hand-mucking is also a problem in blackjack.
Perhaps the most odious way of cheating with a partner is to have a weekly game at your house, agreeing with all your regular players that you split the profit from cheating a single player. This hot-seat game invites a new player every week, only to play against six players all working together. The mechanics are the same, players signal their hands, then play proceeds as to drive the hot-seat out, or to put all his money in the pot.
If you are at a poker game and you detect that your opponents are cheating, but are not very good at it, you can use this information to your advantage. You may be better off exploiting their inept cheating than leaving or turning them in. Whether or not this should also be considered cheating is an interesting question of ethics.

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